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Designing Novel RNA Binders
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1998
Year
EngineeringSpecific Rna BindersBiochemistryStructural BioinformaticsProtein FoldingMedicineRna Structure PredictionRna BiologySynthetic BiologyMolecular BiologyNovel Rna BindersMolecular RecognitionRna StructureGenome EditingStructural BiologyIntimate Knowledge
The successful design of specific RNA binders requires intimate knowledge of RNA structure, folding, and recognition. Investigation of the interactions between aminoglycoside antibiotics (such as kanamycin A and B, R1 = OH and NH2, respectively, R2 = OH) and RNA has unraveled certain recognition rules; we propose a recognition model suggesting three-dimensional electrostatic complementarity and discuss issues of binding specificity and factors that have to be considered in designing new RNA binders.