Chemistry - A European Journal · 1998 · 87 citations · 0 references
PharmacyMedicinal ChemistryMolecular BiologyDrug DesignMolecular RecognitionStructural BiologyLigand BindingRibonucleic Acid (Rna) ChemistryRna ChemistryRna FoldingRna StructureStructural Basis Of RecognitionAminoglycoside AntibioticsBinder DiscoveryMacromolecular Electrostatic ComplementarityMolecular Recognition Of RnaRna Recognition MotifsRna-binding SpecificityStructural Recognition MotifsTertiary Rna Structure
The successful design of specific RNA binders requires intimate knowledge of RNA structure, folding, and recognition. Investigation of the interactions between aminoglycoside antibiotics (such as kanamycin A and B, R1 = OH and NH2, respectively, R2 = OH) and RNA has unraveled certain recognition rules; we propose a recognition model suggesting three-dimensional electrostatic complementarity and discuss issues of binding specificity and factors that have to be considered in designing new RNA binders.