Inhaled endotoxin and organic dust particulates have synergistic proinflammatory effects in equine heaves (organic dust‐induced asthma)

Abstract

Although inhaled endotoxin appears not to be the only determinant of disease severity in heaves, it does contribute significantly to the induction of airway inflammation and dysfunction. This contribution is largely via the synergistic action of inhaled endotoxin and organic dust particulates, although other soluble dust components also contribute to a lesser degree.