The<i>UCP1</i>−3826A/G Polymorphism Is Associated with Diabetic Retinopathy and Increased<i>UCP1</i>and<i>MnSOD2</i>Gene Expression in Human Retina

Abstract

This study suggests that the -3826A/G polymorphism is associated with DR in type 1 DM patients. This is the first report demonstrating UCP1 gene expression in human retinas and indicates that the -3826A/G polymorphism influences its expression. In addition, the -3826G allele was associated with increased MnSOD2 expression; thus, suggesting that this allele could be a marker of oxidative stress.