Comprehensive metabolomics identifies the alarmin uric acid as a critical signal for the induction of peanut allergy

Abstract

Overproduction of the UA alarmin in the local microenvironment plays a critical role in the induction of peanut-allergic sensitization, likely due to its ability to activate DCs. These finding suggest that cellular damage or tissue injury may be an essential requisite for the development of allergic sensitization to foods.