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Adrenoleukodystrophy: correlating MR imaging with CT.
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1987
Year
Neurological DisorderCorticobasal DegenerationWhite MatterMagnetic Resonance ImagingCorrelating MrVascular ImagingNeurologyNeuropathologyRadiologyHealth SciencesCardiovascular ImagingMedical ImagingHigh SensitivityRadiologic ImagingDiagnostic NeuroradiologyMedial Geniculate BodyBiomedical ImagingLateral Geniculate BodyDegenerative DiseaseNeuroscienceMedicine
The study examined 40 boys with X‑linked adrenoleukodystrophy using CT scans and MR imaging. MR imaging demonstrated high sensitivity for detecting white matter disease, while contrast‑enhanced CT more effectively revealed active disease progression and calcifications, and the extensive CT series clarified the broad, variable expression of adrenoleukodystrophy, unifying previously atypical forms.
The effect on the brain of the sex-linked recessive form of adrenoleukodystrophy was studied in 40 boys, 4-18 years old. All underwent computed tomography (CT) scanning; six underwent magnetic resonance (MR) imaging. MR showed a high sensitivity in demonstrating white matter disease. Auditory pathway disease was characterized as involvement of the lateral lemniscus and medial geniculate body, and visual pathway disease was characterized by lateral geniculate body, Meyer loop, and optic radiation involvement. Contrast-enhanced CT still proved to have a greater capacity (at this time) to show the active, advancing form of the disease and concomitant calcifications. This large CT series also demonstrated the broad and variable expressions of adrenoleukodystrophy, which allowed the unification of previously described atypical forms of the disease.