Publication | Closed Access
Tuning Rate of the Bergman Cyclization of Benzannelated Enediynes with Ortho Substituents
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Citations
24
References
2002
Year
Bergman CyclizationBioorganic ChemistryHeterocyclicBiochemistryRational DesignNatural SciencesMolecular BiologyBenzannelated EnediynesOrganic ChemistryChemistryOrtho SubstituentsChemical BiologyHeterocycle ChemistryEnantioselective SynthesisNatural Product Synthesis
[reaction: see text] The Bergman cyclization of benzannelated enediynes is highly sensitive to ortho substitution. This finding opens possibilities for the rational design of conformer-specific and pH-dependent DNA-cleaving agents.
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