Reactions of Oxetan-3-<i>tert</i>-butylsulfinimine for the Preparation of Substituted 3-Aminooxetanes

Abstract

The oxetane ring is useful in drug discovery as a bioisostere for both the geminal dimethyl group and the carbonyl group. A convenient, straightforward approach to access structurally diverse 3-aminooxetanes through the reactivity of oxetan-3-tert-butylsulfinimine and the corresponding sulfinylaziridine is described.