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INFLUENCE OF GONADAL HORMONES ON THE METABOLISM OF CORTISONE
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1959
Year
SpermatogenesisFertilityComparative EndocrinologyNeuroendocrinologyGynecologyFemale HormoneFemale Reproductive FunctionReproductive BiologyReproductive EndocrinologyReproductive MedicinePublic HealthSteroid MetabolismEndocrine MechanismEndocrinologyPhysiologyMale HormoneMetabolismMedicineEndocrine ResearchReproductive HormoneAdult Male Rats
Liver homogenates from adult male rats reduced the 17,21-dihydroxy-20- ketone sidechain of cortisone more rapidly than did similar preparations from female rats. Conversely, the female preparation metabolized the Δ4–3 ketone group at a faster rate than did the male. The ratio A-ring reduction/sidechain reduction for the female is 3.4; for the male it is 0.88. The sex difference in the metabolism of the sidechain of cortisone is not present in rats younger than about 25 days of age but becomes evident by the time the animals are 30 days old. Gonadectomy and injections of estradiol-17β and testosterone indicate that the male hormone promotes the ability of the liver to reduce the sidechain of cortisone while the female hormone has an inhibitory effect.