The Effect of 1.BETA.-Methyl Substituent and the Basicity in C-2 Side Chain in Carbapenem Antibiotics on the Activity against Pseudomonas aeruginosa oprD2 and nalB Mutants.

Abstract

Carbapenemshave potent antibacterial activity and a wide spectrum of action against Gram-positive and Gram-negative bacteria1 ~4). They also show high in vitro and in vivo antibacterial activity against Pseudomonas aeruginosa, which is a clinically important organism.