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The cyclic carbamate unit of maytansine
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1977
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Cyclic Carbamate UnitEnantioselective SynthesisEngineeringHeterocyclicOrganic ChemistryStereoselective SynthesisEleven Step SequenceChemistryRelative StereochemistryBiomolecular Engineering
An eleven step sequence with control of the relative stereochemistry of four asymmetric centers has converted 3,4-epoxycyclohexene into a highly functionalized model for synthesis of the cyclic carbamate unit of maytansine.