Publication | Closed Access
Reaction of Cyclic α-Oxoketene Dithioacetals with Methylene Isocyanides: A Novel Pyrrole Annulation–Ring-Expansion Domino Process
36
Citations
48
References
2013
Year
Bioorganic ChemistryEngineeringMolecular BiologyOrganic ChemistryChemistryHeterocycle ChemistryChemical BiologyChemical EngineeringBiosynthesisStereoselective SynthesisRelevant Annulated PyrrolesDomino ProcessBiochemistryCyclic KetonesMethylene IsocyanidesCatalysisEnantioselective SynthesisBiomolecular EngineeringHeterocyclicNatural SciencesCyclic α-Oxoketene DithioacetalsSynthetic Chemistry
The title reaction provides a direct entry to a range of biologically relevant annulated pyrroles via a domino process involving a regioselective one-carbon homologation of cyclic ketones as the key step.
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