Efficacy of inactivated whole HIV‐2 vaccines with various adjuvants in cynomolgus monkeys

Abstract

Twenty‐one cynomolgus monkeys were immunized with whole inactivated HIV‐2 preparations administered with various adjuvants (incomplete Freund's adjuvant, Alum, Ribi, MDP, or Iscoms) and challenged with 10 or 100 MID 50 of a homologous monkey‐cell grown, cell‐free HIV‐2. Seven animals were completely protected against infection, three showed reduced virus replication. The vaccines elicited neutralizing and ADCC antibodies; the titers did not correlate with protection. Immunization with a whole inactivated vaccine can protect primates from intravenous challenge with a monkey‐cell grown cell‐free human immunodeficiency virus type 2.