Oxepinamides: Novel Liver X Receptor Agonists from <i>Aspergillus puniceus</i>

Abstract

Abstract Four novel oxepin‐containing pyrimidines, namely oxepinamides D–G ( 1 – 4 ), were isolated from cultures of Aspergillus puniceus F02Z‐1744. The structures of 1 – 4 were elucidated by analyzing their spectroscopic data generated by 1D and 2D NMR and MS methods. The configurations of 1 and 2 were established based on single‐crystal X‐ray crystallographic analysis. All four compounds 1 – 4 showed transcriptional activation on Liver X Receptor α (LXRα) with EC 50 values of 10.6, 12.8, 13.6, and 12.1 μ M , respectively.