The angiotensin II receptor antagonist valsartan inhibits endothelin 1–induced vasoconstriction in the skin microcirculation in humans in vivo: Influence of the G-protein β3 subunit (GNB3) C825T polymorphism

Abstract

Our results indicate that the renin-angiotensin system may significantly contribute to ET-1-mediated microvascular responses. Valsartan inhibited local vasoconstriction to angiotensin II and ET-1 to a greater degree in carriers of the GNB3 825T allele, which adds to data from earlier studies implicating the C825T polymorphism as a pharmacogenetic marker for drug effects.