Increased Expression of Tumor Necrosis Factor-α Converting Enzyme and Tumor Necrosis Factor-α in Peripheral Blood Mononuclear Cells in Patients with Advanced Congestive Heart Failure

Abstract

These results demonstrate that in patients with CHF, and especially those with severe CHF, TACE expression in PBMC increases with TNF-alpha expression. These observations suggest that TACE in PBMC is an important regulator of TNF-alpha maturation, meaning that TACE may be a potential target for the inhibition of cellular TNF-alpha production in CHF.