Cinnamic Acid/Chloroquinoline Conjugates as Potent Agents against Chloroquine‐Resistant <i>Plasmodium falciparum</i>

Abstract

Cinnamic acid derivatives containing a 4-amino-7-chloroquinoline scaffold (blue) and substituted cinnamoyl building blocks (green) linked through an alkylamine chain (red) were found to have potent (11-59 nM) in vitro activities against erythrocytic chloroquine- resistant Plasmodium falciparum.