Asian Pacific Journal of Tropical Biomedicine · 2012 · 71 citations · 4 references
The study examined how serum electrolyte alterations relate to cisplatin‑induced nephrotoxicity. Eighteen cancer patients receiving 40–50 mg/day cisplatin had serum electrolytes, creatinine, BUN, and urine potassium, sodium, and pH measured before and after treatment to assess renal injury. Five cisplatin cycles produced significant hypomagnesemia, hypocalcemia, hypophosphatemia, hypokalemia, and elevated creatinine (and BUN), with urinary potassium loss but unchanged sodium and pH, indicating acute nephrotoxicity driven by electrolyte disturbances in the absence of correction.
To investigate the relationship between serum electrolyte changes and cisplatin induced nephrotoxicity. We collected data from 18 patients undergoing cisplatin chemotherapy including serum electrolytes, creatinine, blood urea nitrogen (BUN) and urine potassium, sodium and pH levels before and after the cisplatin chemotherapy. All the patients had cancer and were treated with 40–50 mg/day cisplatin. Renal injury was assessed by measuring serum electrolytes, creatinine, BUN levels and urine potassium, sodium and pH levels. The five cycles of cisplatin based chemotherapy resulted in hypomagnesia (P=0.029), hypocalcaemia (P=0.001*), hypophosphatemia (P=0.003*), hypokalemia (P=0.001*) and increased serum creatinine (P=0.001*) and BUN (P=0.292*) levels. In urine analysis, decrease in potassium (P=0.024*) was found, except potassium there was no significant changes in sodium and urine pH. The present study demonstrates that, acute nephrotoxicity was observed in patients with different types of cancers undergoing cisplatin based chemotherapy due to electrolyte disturbances, when no corrective measures were initiated.
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Lubomir Bodnar, Gabriel Wcisło, Agnieszka Gąsowska-Bodnar et al. · European Journal of Cancer · 2008 · 109 citations