Regulation of inflammatory responses and fibroblast‐like synoviocyte apoptosis by calcineurin‐binding protein 1 in mice with collagen‐induced arthritis

Abstract

Our findings demonstrate that hCABIN-1 plays a critical role in promoting apoptosis of FLS and in attenuating inflammation and cartilage and bone destruction in RA. These results help elucidate the pathogenic mechanisms of RA and suggest that CABIN-1 is a potential target for treatment of this disease.