Induction of Tumors in Hamsters with an Avian Adenovirus (CELO)

Abstract

When newborn hamsters were inoculated subcutaneously with chicken-embryo lethal orphan virus, tumnors developed at the site of inoculation in 23 out of 69 hamsters within 88 to 195 days of inoculation. These tutlnors and tissue cultures, prepared from a primary tumor, were transplantable to newborn and weanling hamsters. The primary tumnors and tissue cultures of a primary tumor were free of demnonstrable infectious virus. The virus is the first "nonhuman" adenovirus found to induce tumors in hamsters.