Enkephalin-induced inhibition of cortical neurones and the lack of this effect in morphine tolerant/dependent rats

Identification of two related pentapeptides from the brain with potent opiate agonist activity

Joel W. Hughes, Terry Smith, H. W. Kosterlitz et al. · Nature · 1975 · 3.8K citations

Neurophysiology, Neuroanatomy, Related Pentapeptides +11

Opiate Receptor: Demonstration in Nervous Tissue

Candace B. Pert, Solomon H. Snyder · Science · 1973 · 2.4K citations

Powerful Opiate Antagonist, Psychoactive Drug, Medicine +12

Isolation of an endogenous compound from the brain with pharmacological properties similar to morphine

John Hughes · Brain Research · 1975 · 980 citations

Molecular Pharmacology, Psychoactive Drug, Pharmacological Study +13

Development of physical dependence on morphine in respect to time and dosage and quantification of the precipitated withdrawal syndrome in rats

J. Bl�sig, A. Herz, Kimberly Reinhold et al. · Psychopharmacology · 1973 · 529 citations

Substance Abuse, Psychoactive Drug, Substance Use +14

An endogenous morphine-like factor in mammalian brain

Gavril W. Pasternak, Robert Goodman, Solomon H. Snyder · Life Sciences · 1975 · 392 citations

Molecular Neuroscience, Neurophysiology, Neuroanatomy +9