Determination of methotrexate and its major metabolite 7-hydroxymethotrexate in mouse plasma and brain tissue by liquid chromatography-tandem mass spectrometry

Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport.

Hao Zeng, Zhe‐Sheng Chen, Martin G. Belinsky et al. · PubMed · 2001 · 257 citations

Molecular Pharmacology, Cellular Mtx Efflux, Mtx Transport +14

Liquid−Liquid Extraction in the 96-Well Plate Format with SRM LC/MS Quantitative Determination of Methotrexate and Its Major Metabolite in Human Plasma

Simon T. Steinborner, Jack D. Henion · Analytical Chemistry · 1999 · 132 citations

Methotrexate cross-resistance in a mitoxantrone-selected multidrug-resistant MCF7 breast cancer cell line is attributable to enhanced energy-dependent drug efflux.

Erin L. Volk, Kyle H. Rohde, M. Rhee et al. · PubMed · 2000 · 124 citations

Methotrexate Cross-resistance, Breast Oncology, Mtx Resistant +16

The effect of P-glycoprotein on paclitaxel brain and brain tumor distribution in mice.

James M. Gallo, Shaolan Li, Ping Guo et al. · PubMed · 2003 · 105 citations

Neuro-oncology, Tumor Biology, Tumor Innervation +15

Microdialysis probes calibration: Gradient and tissue dependent changes in No Net Flux and reverse dialysis methods

Anne Le Quellec, Sylvie Dupin, Patrick Genissel et al. · Journal of Pharmacological and Toxicological Methods · 1995 · 79 citations

Hemodialysis, Renal Function, Kidney Failure +9