Journal of Toxicology Clinical Toxicology · 1986 · 23 citations · 9 references
PharmacyPharmacokineticsPharmacologyClinical PharmacologyPediatric Clinical PharmacologyPediatric PharmacotherapyLocal Anesthetic ToxicityPediatric AnesthesiaPediatric Drug DosingPediatric PharmacokineticsPediatric PharmacologyChild DosingDrug Overdose In ChildrenIntravenous LidocaineLidocaine PharmacokineticsPediatric Injectable AnesthesiaPediatric Overdose ManagementSeizuresTotal Dose
A six-year-old child inadvertently received an IV solution containing lidocaine HCl. An estimated total dose of 1.2 gm. was administered over approximately an hour. The child had asystole and grand mal seizures associated with lidocaine serum concentration of 19.2 mcg/ml. The pharmacokinetics of lidocaine overdose and treatment are discussed.
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Pharmacokinetics of lidocaine in man
R N Boyes, D.B. SCOTT, Peter Jebson et al. · Clinical Pharmacology & Therapeutics · 1971 · 228 citations
Lidocaine Toxicity from Topical Mucosal Application
Howard C. Mofenson, Thomas R. Caraccio, Harvey Miller et al. · Clinical Pediatrics · 1983 · 90 citations