Proceedings of the National Academy of Sciences · 1983 · 56 citations · 15 references
Electrolyte DisorderCanine KidneyHuman Cerebrospinal FluidSocial SciencesOuabain-like ActivityCerebrospinal FluidElectrolyte DisturbanceIntracranial PressureCognitive ElectrophysiologyEdemaClinical ChemistryOsmoregulationAnimal PhysiologyNeuropharmacologyCerebral Blood FlowNervous SystemPharmacologyNeurophysiologyPhysiologyNeuroscienceElectrophysiologyCentral Nervous SystemMetabolismMedicine
Human cerebrospinal fluid has been found to mimic the effect of ouabain on net Na+ efflux and 86Rb+ influx across erythrocyte membranes and on the in vitro activity of a purified Na+/K+-ATPase (ATP phosphohydrolase, EC 3.6.1.3) derived from canine kidney. These results indicate the possible existence in human cerebrospinal fluid of an endogenous factor with ouabain-like activity, which might be linked to sodium metabolism.
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