Prostate‐specific antigen stimulates osteoprotegerin production and inhibits receptor activator of nuclear factor‐KappaB ligand expression by human osteoblasts

Abstract

Based on our findings, PSA acts on human osteoblast-like cells via its own serine protease activity and promotes osteoblast differentiation. In addition, PSA stimulates OPG production and inhibits RANKL expression of osteoblasts, and inhibits bone resorption by osteoclasts, suggesting that it contributes to the characteristic osteoblastic features of bone metastases of prostate cancer.