First Experience of ¹⁸F-Alfatide in Lung Cancer Patients Using a New Lyophilized Kit for Rapid Radiofluorination

Abstract

(18)F-alfatide can be produced with excellent radiochemical yield and purity via a simple, 1-step, lyophilized kit. PET scanning with (18)F-alfatide allows specific imaging of αvβ3 expression with good contrast in lung cancer patients. This technique might be used for the assessment of angiogenesis and for planning and response evaluation of cancer therapies that would affect angiogenesis status and integrin expression levels.