Progression of signet ring cell carcinomas in the human stomach

Abstract

In signet ring cell carcinoma, aneuploid cells show higher invasive activity toward the extramucosal part and may occur incidentally in originally diploid tumors, depending on the degree of genetic instability. An analysis of polyploidy is useful for differentiating cytometrically diploid (but actually, aneuploid) cells from diploid cells with minor genetic abnormalities.