Cytotoxic Effect of Nanocrystalline MgFe₂O₄ Particles for Cancer Cure

Abstract

Nanocrystalline magnesium ferrites (MgFe 2 O 4 ) were produced with an average grain size of about 20 nm. Their structural, morphological, and magnetic characterizations were studied. The cytotoxic effects of MgFe 2 O 4 nanoparticles in various concentrations (25, 50, 100, 200, 400, and 800 μ g/mL) against MCF‐7 human breast cancer cells were analyzed. MTT assay findings suggest the increased accumulation of apoptotic bodies with the increasing concentration of MgFe 2 O 4 nanoparticles in a dose‐dependent manner. Flow cytometry analysis shows that MgFe 2 O 4 nanoparticles in 800 μ g/mL concentration are more cytotoxic compared to vehicle‐treated MCF‐7 cells and suggests their potential utility as a drug carrier in the treatment of cancer.