Early decline in the catecholamine release-inhibitory peptide catestatin in humans at genetic risk of hypertension.

Abstract

We conclude that catestatin is diminished early in the course of development of hypertension, even in the normotensive offspring of patients with the disease. Low catestatin predicts augmented adrenergic pressor responses, suggesting a mechanism whereby diminished catestatin might increase the risk for later development of hypertension.