Bone marrow scintigraphy in the early diagnosis of experimental metastatic bone carcinoma

Abstract

Paralleled experimental studies of radioisotopic bone marrow imaging, bone scanning, and skeletal radiologic survey were undertaken upon the intramedullary-implanted and hematogenously metastatic VX-2 rabbit bone carcinoma in order to see their temporal relationship in delineating such lesions. Both bone and bone marrow scans turned positive far earlier than the x-rays. Moreover, lesion-depicting marrow scans were obtainable before the bone scans became positive. Radiocolloidal marrow scanning appears to be one of the techniques of choice in the early diagnosis of metastatic skeletal malignancies.