Remarkable Template Effect of a Lewis Acidic Receptor in Intramolecular Radical Cyclizations

Abstract

The bowl-shaped reaction environment created by the Lewis acid aluminum tris(2,6-diphenylphenoxide) has been utilized as an efficient template in intramolecular radical cyclizations. The pathway and the stereoselectivity of the radical cyclization can be altered by using this template. A schematic representation of the transition state of the template assisted reaction is shown on the right.