Asymmetric synthesis of (1R,1′R)- and (1S,1′S)-bis(1-arylethyl)amines by way of a diastereoselective addition to chiral imines and oxaxolidines with organometallic reagents

Abstract

The asymmetric synthesis of the bis(α-methylbenzyl)amines, (1R,1′R)- and (1S,1′S)-bis(1-arylethyl)-amines 6, utilizing a diastereoselective reaction of chiral imines and oxazolidines derived from (R)-phenylglycinol with Organometallic reagents, is described.