NADH‐Dependent Halogenases Are More Likely To Be Involved in Halometaolite Biosynthesis Than Haloperoxidases

Abstract

NADH instead of hydroged peroxide is required by two newly identified, substrate-specific and regioselective halogenases. Both were isolated from a pyrrolnitrin-producing Pseudomonas fluorescens strain. One enzyme catalyzes the chlorination of L-tryptophan to 7-chloro-L-tryptophan (1).