Paclitaxel Poliglumex, Temozolomide, and Radiation for Newly Diagnosed High-grade Glioma

Abstract

PPX could not be safely combined with temozolomide due to grade 4 hematologic toxicity. However, the favorable progression-free and overall survival suggest that PPX may enhance radiation for glioblastoma. A randomized study of single agent PPX/radiation versus temozolomide/radiation for glioblastoma without MGMT methylation is underway.