Unusual Serum Lipoprotein Abnormality Induced by the Vehicle of Miconazole

Abstract

Miconazole, a phenethylimidazole,1 is effective in vitro against several pathogenic fungi,1 , 2 and has cured systemic mycoses in man.3 , 5 In contrast to amphotericin B, miconazole does not appear to have renal or hematologic toxicity.3 , 4 On the theory that miconazole might be as effective as and less toxic than amphotericin B, three patients with deep mycotic infections were treated with this drug intravenously after informed consent was obtained. Elevated serum lipid concentrations developed. In Case 1, only serum lipid concentrations were determined; in Cases 2 and 3, an unusual lipoprotein electrophoretic pattern was detected.Case ReportsCase 2. A 44-year-old woman had . . .