Blockade of the interleukin‐7 receptor inhibits collagen‐induced arthritis and is associated with reduction of T cell activity and proinflammatory mediators

Abstract

Blockade of IL-7Rα potently inhibited joint inflammation and destruction in association with specific reductions of T cell numbers, T cell-associated cytokines, and numerous mediators that induce inflammation and tissue destruction. This study demonstrates an important role of IL-7R-driven immunity in experimental arthritis and indicates the therapeutic potential of IL-7Rα blockade in human arthritic conditions.