Efficacy against <i>Fasciola hepatica</i> and the pharmacokinetics of triclabendazole administered by oral and topical routes

Abstract

TCBZ administered orally at 12 mg/kg resulted in greater efficacy against 28-day-old, early immature liver fluke than was achieved by topical administration at 30 mg/kg. Plasma metabolites of TCBZ were higher and liver pathology was less in TOS-treated animals than in TA-treated animals.