Influence of Oligodeoxyribonucleotides on the Immune Response of Newborn AKR Mice.

Abstract

Oligodeoxyribonucleotides, administered to newborn AKR mice in conjunction with sheep red blood cells, influence the time of appearance of hemolysin-forming cells in pancreatic and mesenteric lymph nodes. Thus, in comparison with animals that received the antigen only, 5- and 7-day-old animals injected with antigen and oligodeoxyribonucleotides, subsequently showed hemolysin-forming lymph node cells one to 3 days earlier. Such differences were not detected in assays on spleen cell populations and circulating hemolysins. The sequence of first appearance of antibody-producing cells in the organs assayed was spleen→pancreatic lymph nodes→mesenteric lymph nodes, and this sequence was not affected by administration of oligodeoxyribonucleotides.