Chiral Scandium-catalyzed Highly Stereoselective Ring-opening of <i>meso</i>-Epoxides with Thiols

Abstract

Abstract The desymmetrization of meso-epoxides with thiols proceeded smoothly in dichloromethane or dichloroethane in the presence of a catalytic amount of a chiral scandium complex consisting of Sc(OTf)3 and chiral bipyridine 1, to afford the corresponding sulfides in high yields with high enantioselectivities.