Biotechnology and Bioengineering · 1974 · 10 citations · 5 references
EngineeringChemical EngineeringFluid DynamicsProcess DynamicsTransport PhenomenaFlow ModelingMass TransferMass Transfer DynamicsMass TransportStirred-tank BioreactorsTurbulent MixingContinuous FlowContinuous MixingImpeller HydrodynamicsMixing BehaviorMixing DynamicsMixing Dynamics In Bioreactor VesselsOperating ConditionsPerfect Mixing Model
Abstract System response data for step changes in input tracer concentration have been obtained for two different impeller agitated continuous flow mixing systems containing aqueous polysaccharide solutions. The vessel volumes were 1.6 and 10.9 liters. Polysaccharide concentration, dilution rate, and impeller speed were varied according to a plan devised using dimensional analysis and assuming that bulk motion is the predominant mass transport mechanism in the system. The data show that this is not true and that serious errors may occur if scale‐up calculations are based on assuming that bulk motion predominates. Under the operating conditions used, perfect mixing was not observed.
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P.V. Danckwerts · Chemical Engineering Science · 1953 · 2.6K citations
Dimensional analysis and theory of models
Otto Spies · Journal of the Franklin Institute · 1952 · 665 citations
PROCESS ANALYSIS AND SIMULATION
Unikl Micet · 2015 · 188 citations