Neurology · 2004 · 79 citations · 8 references
Life SciencesGeneticsMolecular GeneticsHuman GeneticsMedical GeneticsNeurogeneticsCytokine Gene PolymorphismGenetic Risk FactorsGenetic SusceptibilityGenotype-phenotype Association AnalysisHeadache DisordersInnate Immune Gene PolymorphismsDisease Susceptibility AssociationDisease-specific Risk AllelesMigraine AssociationMigraine AuraMigraine With AuraMigraine Without AuraTumor Necrosis Factor Alpha VariantsTumor Necrosis Factor Gene Variants
In a group of 299 migraine patients and 306 control subjects, the association of the -308 G/A polymorphism in the tumor necrosis factor-alpha gene (TNFalpha) with the occurrence and clinical characteristics of migraine was tested. Homozygosity for the G allele was associated with an increased risk of migraine (odds ratio [OR] = 2.85, p < 0.001). When the patients were divided into subgroups, the association was confirmed in patients affected by migraine without aura (OR = 3.30, p < 0.001) but not in migraine with aura. These data suggest that the TNFalpha gene or a linked locus significantly modulates the risk for migraine.
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Influence of TNFα gene polymorphisms on TNFα production and disease
Ali H. Hajeer, Ian V. Hutchinson · Human Immunology · 2001 · 314 citations
Life Sciences, Genetics, Immunology +14