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QUANTITATIVE STUDY OF THE HISTOCOMPATIBILITY ANTIGENS ON THE SURFACE OF NORMAL AND LEUKAEMIC CELLS IN MICE I. Variations in the Expression of Groups of H-2 Specificities in Four Leukemias Induced by 7, 12-Dimethyl-benz (a) anthracene
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1973
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HistocompatibilityImmunologyPathologyImmunophenotypingImmunotherapeuticsImmune SystemTumor BiologyHematological MalignancyH-2 SpecificitiesFour Leukemias InducedSummary FourHematologyCancer Cell BiologyF1 Hybrid MiceMurine LeukaemiasImmune SurveillanceAutoimmunityQuantitative StudyCell BiologyMalignant Blood DisorderAdult T-cell Leukemia-lymphomaMedicine
SUMMARY Four murine leukaemias, induced by 7,12-dimethyl-benz (a) anthracene (DMBA) in (DBA/2 × C57BL/6)F1 hybrid mice have been studied for their H-2 antigenic constitution. Different oligospecific isoantisera have been absorbed with various quantities of each type of leukaemic cell and with normal cells from spleen, thymus, and lymph node for comparison. One of these leukaemias shows a general diminution of all the H-2 specificities without detectable qualitative loss. The loss of some H-2 specificities has been demonstrated on the three others, but those specificities lost varied from one leukaemia to another. In one case, an increase of one or more specificities has been observed. It seems that the affinity between the H-2 specificities and the antibodies of one given antiserum can differ with different leukaemias. No relation between H-2 expression and the number of leukaemic cells giving 50% mortality in the syngeneic host has been found.