Formation of CSCF₃ Bonds through Direct Trifluoromethylthiolation

Abstract

Modern chemistry with an old substituent: The introduction of the SCF3 group into organic substrates is a challenging task because of harsh or specific synthetic methods. However, recent advances in the formation of CSCF3 bonds include the trifluoromethylthiolation with transition-metal-free systems or in the presence of palladium, nickel, or copper catalysts (see scheme).