HETEROGENEITY OF GONADOTROPIN RESPONSE TO LHRH IN HYPOGONADOTROPIC HYPOGONADISM

Abstract

A group of six hypogonadal males with low serum levels of FSH and LH, and otherwise normal pituitary function, underwent tests in which 100-300 ug of LHRH [Luteinizing Hormone Releasing Hormone] was injected rapidly intravenously. All four possible combinations of serum LH and FSH responses were observed. That is, failure of FSH and LH to rise; an increase in both FSH and LH; and an increase in FSH only, or in LH only. The heterogeneity of the LH and FSH responses to LHRH indicates the complexity of the etiology of this group of disorders, whose clinical expression is hypogonadotropic hypogonadism.