Concepedia

Viral MRI contrast agents: coordination of Gd by native virions and attachment of Gd complexes by azide–alkyne cycloaddition

Duane E. Prasuhn, Robert M. Yeh, André Obenaus, Marianne Manchester, M. G. Finn

Chemical Communications · 2007 · 203 citations · 32 references

DOI

Concepts

Abstract

Icosahedral virus particles decorated with a Gd(DOTA) analogue by Cu-mediated azide-alkyne cycloaddition (CuAAC) and/or with Gd(3+) ions by coordination to the viral nucleoprotein show increased T(1) relaxivity relative to free Gd(DOTA) complexes in solution.

References

32

Bioconjugation by Copper(I)-Catalyzed Azide-Alkyne [3 + 2] Cycloaddition

Qian Wang, Timothy R. Chan, Robert Hilgraf et al. · Journal of the American Chemical Society · 2003 · 1.6K citations

, , +12

Viruses: Making Friends with Old Foes

Trevor Douglas, Mark Young · Science · 2006 · 606 citations

, , +14

Dual-Surface Modification of the Tobacco Mosaic Virus

Tara L. Schlick, Zhebo Ding, Ernest W. Kovacs et al. · Journal of the American Chemical Society · 2005 · 512 citations

, , +17

Icosahedral Virus Particles as Addressable Nanoscale Building Blocks

Qian Wang, Tianwei Lin, Liang Tang et al. · Angewandte Chemie International Edition · 2002 · 397 citations

, , +16

Discovery and Characterization of Catalysts for Azide−Alkyne Cycloaddition by Fluorescence Quenching

Warren G. Lewis, Fernando G. Magallon, Valery V. Fokin et al. · Journal of the American Chemical Society · 2004 · 356 citations

, , +17