Clarithromycin‐resistance and point mutations in the 23S rRNA gene in <i>Helicobacter pylori</i> isolates from Japan

Abstract

The results suggest that the point mutation in the 23S rRNA gene is commonly seen in clarithromycin-resistant H. pylori and it contributes to the treatment failure in Japan. The PCR-RFLP system is a sensitive method by which to diagnose H. pylori infection as well as a simple method for detecting clarithromycin resistance without bacterial culture.