Rh‐Catalyzed Amination of Ethereal C^αH Bonds: A Versatile Strategy for the Synthesis of Complex Amines

Abstract

Intramolecular CH insertion with sulfamates catalyzed by rhodium complexes offers an effective method for the preparation of N,O-acetals, which function as iminium ion precursors and undergo smooth diastereoselective coupling with nucleophiles under Lewis acidic conditions (see scheme). These findings advance the versatility of catalytic CH amination for the assembly of structurally complex nitrogen-containing products. Tf=trifluoromethanesulfonyl. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2004/z460791_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.