Neurology · 2000 · 95 citations · 7 references
MedicineNeurologyNeuroscienceMolecular DiagnosticsNeuroimmunologyNeuropathologyCerebrospinal Fluid BiomarkersCreutzfeldt-jakob DiseaseAssayAssay DeterminationCerebrospinal Fluid 14-3-3 ProteinCerebrospinal Fluid MarkersCerebrospinal Fluid Protein StudiesDiagnosis Of Creutzfeldt-jakob Disease
The definitive diagnosis of Creutzfeldt-Jakob disease (CJD) requires brain tissue analysis. A positive assay for the 14-3-3 protein in CSF has been suggested to be highly sensitive and specific in patients with CJD. The authors describe three patients for whom CSF 14-3-3 assays were falsely positive or falsely negative. Caution against overreliance on this putative biomarker is suggested in the diagnosis of CJD.
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Transmissions to mice indicate that ‘new variant’ CJD is caused by the BSE agent
M. E. Bruce, Robert Will, James W. Ironside et al. · Nature · 1997 · 2K citations
How to improve the clinical diagnosis of Creutzfeldt–Jakob disease
S. Poser, Brit Mollenhauer, Angela Krauβ et al. · Brain · 1999 · 199 citations · Full text