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A Selective and Efficient Method for the Deprotection of N-Benzyloxymethyl (BOM) Protecting Groups from Pyrimidine and Dihydropyrimidine Ring Systems
12
Citations
8
References
1988
Year
Combinatorial ChemistryDerivative (Chemistry)Bioorganic ChemistryDerivativesBiochemistryEfficient MethodNatural SciencesEngineeringDihydropyrimidine Ring SystemsChemical DerivativeFluorous SynthesisN3-dibenzyloxymethyl DerivativesOrganic ChemistryN-bom DerivativesPharmacologyPharmaceutical ChemistryBiomolecular EngineeringAbstract N1
Abstract N1,N3-dibenzyloxymethyl derivatives of pyrimidines and dihydropyrimidines have been successfully deprotected by using trifluoroacetic acid (TFA). These N-BOM derivatives can be selectively removed from a variety of derivatives including nucleosides and compounds which are sensitive to base and reducing conditions.
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