Diuretic and antidiuretic diuretic of the leaf extracts ofVernonia cinerea (Less) (Fam. Compositae)

Abstract

The diuretic and anti-diuretic potency of the leaf extracts of Vernonia cinerea was studied in albino rats. The chloroform extract of the leaf induced significant diuresis, while the methanol and aqueous extracts induced significant antidiuresis in rats. In both cases, the observed effects on urine volume and electrolyte excretion were dose dependent. The trend was a significant increase (in the case of diuresis) in natriuretic and kaliuretic activity and a significant decrease (in the case of antidiuresis) in natriuresis and kaliuresis. © 1997 John Wiley & Sons, Ltd.