Genetically Engineered Bacteria-Based BioTransceivers for Molecular Communication

Abstract

Molecular Communication (MC) is a nano-scale communication paradigm where the information is carried by molecular signals. To establish information transmission using molecules, biological nanomachines can be utilized as transmitters and receivers. A bacteria can be programmed as a biotransceiver by modifying their genetic code to implement biological circuits. In this paper, genetically engineered bacteria-based biotransceivers are investigated for MC, where bacteria can generate and respond to the molecular signals. A biochemical model of biological circuits is presented, and both analog and digital signaling are studied. The challenges in connecting basic biological circuits to build these blocks are revealed. A biotransceiver architecture is introduced that combines sensing, transmitting, receiving and processing blocks. Furthermore, biological circuit design framework is proposed for transmission of signals with M-ary pulse amplitude modulation. The biological circuits designed for biotransceiver are elaborated via numerical results based on biochemical parameters of the genetically engineered bacteria. The provided results show that using biological circuits, bacteria can function as a transmitter and receiver node for MC. Our work stands as a basis for future biotransceiver design for MC.